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We are a clinical-stage, Phase 2 Company
Accelerating 1st-in-class precision therapies for inflammatory & rare diseases
We accelerated from Early Discovery to Phase 2 in
2.5 years with seed capital
PIPELINE
Our lead programs
We have 3 key programs in different phases across two different targets. All of these use novel 1st-in-class therapies developed by GEn1E using the relevant modality to treat the disease effectively.
PROBLEM
Kinase dysregulation contributes to various inflammatory diseases
p38, MK2, ERK kinase dysregulation contributes to pathogenesis of several devastating inflammatory diseases and therefore are attractive targets.
Previous attempts to address this dysregulation involved kinase inhibitors which were immunosuppressive and encountered issues including off-target effects, toxicity, lack of specificity, and the potential for severe medical complications.
The reason for these issues is because targeting these kinases with specificity and without disrupting normal cellular functions is a complex task.
Previous attempts to address this dysregulation involved kinase inhibitors which were immunosuppressive and encountered issues including off-target effects, toxicity, lack of specificity, and the potential for severe medical complications.
The reason for these issues is because targeting these kinases with specificity and without disrupting normal cellular functions is a complex task.
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Our Solution
1. Discovery of a new Binding Pocket
Traditional kinase inhibitors focus on the ATP binding pocket with covalent bonding. Our platform allows us to identify new binding pockets where we can target specific functions using allosteric binding.
2. A unique & validated MOA (presented at ATS 2023 and ATS 2024)
GEn1E’s novel compounds bind to a unique binding site. Unlike previous generation compounds which are non-selective and immunosuppressive due to their inhibitor characteristics, GEn1E’s selective & dual signal modifiers use a differentiated Mechanism of Action for treating inflammation.
GRID ™ AI platform by GEn1E, for GEn1E
GEn1E has developed a unique technology platform for treating rare and inflammatory diseases, with a particular focus on Next Generation substrate-specific p38α kinase inhibitors. The key aspects of this platform include a rich database of curated public and proprietary data, which connects the dots between genes, pathways, proteins, diseases, and our compounds. Additionally, the Machine Learning models trained using this data span the entire process chain from drug discovery to clinical trials accelerating the drug development cycle for GEn1E drugs.
Outputs
21
1st-in-class compounds
1
Asset in Phase 2
3
Preclinical programs
2.5
Years
Seed
Spend
Unique scalability
Unlocking a $100 Billion+ opportunity
With our mantra of Team + Tech + Target we have enabled a unique and scalable drug development model. We use this model for developing novel 1st-in-class therapies with unprecedented efficiencies. Combining this approach with strategic partnerships enables us to turbocharge and address large unmet needs of devastated patients.
Respiratory
ARDS
$20B
Asthma
$40B
Neuro Degenerative
Vascular Dementia
$5B
Nephrology
Lupus Nephritis
$5B
AKI
$2B
Transplant Rejection
$1B
Musculo Skeletal
Arthritis
$60B
Dermatology
Thermal Injury
$2B
Atopic Dermatitis
$6B
News, PublicatIons & Events
The latest from GEn1E
Stay updated on groundbreaking achievements, explore noteworthy publications, and mark your calendar for upcoming events that shape our collective story.
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